Fredd's B12 Methylation Protocol

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Fredd has tailored his own B12 methylation protocol by extensive trial and error. He advocates the use of methylcobalamin (methylb12) and adenosylcobalamin (adenosylb12), forms he regards as more bioavailable, not hydroxycobalamin (hydroxyb12) which is advocated by Rich, or cyanocobalamin (cyanob12). Most of the cofactors and supplements in Fredd's protocol can be obtained at any health food store.

A lengthy forum discussion of Fredd's B12 methylation protocol can be found on Phoenix Rising.

Program Basics




Dibencozide (adb12)

B12 Order

  1. Metafolin 15 minutes before eating, attempting top preload the receptors with Metafolin
  2. Food with rest of vitamins, Metafolin 15 minutes after eating
  3. Adb12 15 minutes following Metafolin
  4. Metafolin 1 hour into adb12

Cofactor Order

  1. SAM-e,
  2. L-carnitine fumarate & ALA,
  3. TMG
  4. D-ribose

Benefits of Adenosylb12 and Methylb12

Adenosylb12 (Dibencozide) populates mitochondria and oxidizes fuel into ATP. Severe muscle fatigue goes away. Tender spots and knots in muscles go away. Muscles that usually contract until exhausted and then cease contracting and just be sore and exhausted will recover. Muscles recover in all sorts of ways: reduced pain, grow, heal and become exercise tolerant with adb12. Muscles came back more densely. Energy increases massively with adb12. Neurology becomes more functional and mood improves with adb12, after months of being saturated with mb12.

Methylb12 affects mood, most neurology not affected by neuronal mitochondria, personality, energy, neurological pain, neurological and neuropsychiatric healing and healing of most all tissues, ie endothelial, epithelial, neurological, blood, immune, except muscles. So burning bladder, burning tongue, dermatitis, inflammed stomach, intestines, lungs all should get better with mb12.

Full supplement list

Product Brand Dosage Cost Supply Purpose
Absolutely critical minimums for basic healing
MethylB12 Jarrow Formulas, Methyl B-12, 5000 mcg, 60 Lozenges 5mg under upper lip or tongue for at least 45m $17.97 2mths
AdenosylB12 Source Naturals, Dibencozide, Sublingual, 60 Tablets 3mg under upper lip or tongue for at least 45m $21.27 2mths
Methylfolate Solgar, Folate Metafolin Folic Acid, 800 mcg, 100 Tablets 1 tab/day, preferably at mealtime $12.40 3mths
B-complex Thorne Research, B-Complex #6, 60 Veggie Caps 1 cap 2xday $13.82 1mth
Inositol Jarrow Formulas, Inositol, 8 oz (227 g) 1/24 tsp, 2xday $16.17 forever
Potassium Nature's Way, Potassium Chelate, 99 mg, 100 Capsules 2-3 tabs/day, preferably at mealtime $4.34 1.6mths Insurance against hypokalemia triggered by sudden healing
Omega3 Fish Oils 2-6+ caps/day Essential for myelin sheathing for the nerves
Essential - usually needs supplementing
Zinc Natural Factors, Zinc Chelate, 25 mg, 90 Tablets 2 tabs/day, preferably at mealtime $4.77 1.5mths
Vitamin C Now Foods, Calcium Ascorbate 100% Pure Buffered Vitamin C Powder, 8 oz (227 g) 1/4tspx2/day-1/4tspx4/day (4000+mg/day) $12.10 1.7mths
Magnesium Carlson Labs, Chelated Magnesium, 180 Tablets 2 tabs/day (400mg) $19.92 2.6mths
Vitamin D Now Foods, Vitamin D-3, 2000 IU, 240 Softgels 3000-5000 IU total $9.38 2.6mths
A&D from fish oil
Vitamin E Now Foods, Gamma E Complex, Advanced, 120 Softgels 2 gels/day $13.80 2mths
Possibly Critical Showstopper Cofactors - add after initial stages, any number of these in any combination may be required for maximum effectiveness or in some cases to work at all
SAM-e Doctor's Best, SAMe 200, 60 Enteric Coated Tablets 200-400mg/day $18.89 2mths Makes methylb12 more effective, possibly much more effective, increases energy, improves mood
TMG Jarrow Formulas, TMG 500, 500 mg, 120 Easy-Solv Tablets 1 tab/day $7.77 4mths Enhances SAM-e, methylb12, l-carnitine
L-carnitine fumarate Doctor's Best, Best L-Carnitine Fumarate, 855 mg, 180 Veggie Caps 2 caps/day $31.01 3mths Works with adenosylb12, lack can completely prevent effectiveness of adenosylb12, increases energy, aerobic endurance, improves mood
Alpha Lipoic Acid Healthy Origins, Alpha Lipoic Acid, 100 mg, 120 Capsules 1 cap/day $7.84 3mths Enhances l-carnitine and adenosylb12
D-Ribose Healthy Origins, D-Ribose, 10.6 oz (300 g) 1x5gm/day-3x5gm/day $27.98 1.5mths Enhances adenosylb12, l-carnitine, alpha lipoic acid, improves exercise recovery and energy


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